(Or, you can hold Ctrl as you take a screenshot - Command+Ctrl+Shift+3, for example. png file on your desktop, and you can open it in Preview to begin editing it. If you’d like to take a screenshot and edit it, you can press Command+Shift+3 to snap a screenshot of your entire screen, Command+Shift+4 to snap a screenshot of a selectable area, or Command+Shift+5 to snap a screenshot of only the current window. You can then edit the image and get it back onto your clipboard by clicking Edit > Copy.
Or, with Preview open, you can click File > New From Clipboard to import an image file from your clipboard. From Preview, you can open the image file directly. You can also open the Preview app from the Applications folder, Launchpad, or by pressing Command + Space to open Spotlight Search and searching for Preview.
If you’ve changed your image file associations, you can Command-click or right-click on an image file, point to Open With, and select Preview. By default, you can simply double-click an image file and it will open in Preview. RELATED: Use Your Mac's Preview App to Merge, Split, Mark Up, and Sign PDFs